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Tirzepatide (LY3298176)

Tirzepatide hydrochloride (LY3298176 hydrochloride) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is being developed for the treatment of type 2 diabetes [1] .

In HEK293 cells, Tirzepatide induces internalization of the GIPR and has a propensity toward partial agonism, and this ultimately reflects in signaling bias toward the cAMP pathway versus β-arrestin recruitment. [1] LY3298176 shows glucose-dependent insulin secretion and improves glucose tolerance by acting on both GIP and GLP-1 receptors in mice.

 

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Description

Buy Tirzepatide Online 99% powder.  Tirzepatide (also know as LY3298176) is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is develope for the treatment of type 2 diabetes. Also, The efficacy and safety of co-stimulation of the GLP-1 and GIP receptors with LY3298176 compare with placebo or selective stimulation of GLP-1 receptors with dulaglutide in patients with poorly control type 2 diabetes are examine. However, The dual GIP and GLP-1 receptor agonist, show significantly better efficacy with regard to glucose control and weight loss than did dulaglutide, with an acceptable safety and tolerability profile. More so, Combine GIP and GLP-1 receptor stimulation might offer a new therapeutic option in the treatment of type 2 diabetes.

References: Lancet. 2018 Nov 17;392(10160):2180-2193.

What is Tirzepatide

Tirzepatide (LY3298176, GIP/GLP-1 RA, TZP) is a dual GIP/GLP-1 receptor agonist. Furthermore, Tirzepatide differentially induces internalization of the GIP and GLP-1 receptors with EC50 values of 18.2 nM and 18.1 nM, respectively. However, Next day delivery by 10:00 a.m. Order now. Also, Tirzepatide (LY3298176, GIP/GLP-1 RA, TZP) is a dual GIP/GLP-1 receptor agonist.

What is Tirzepatide   used for

Tirzepatide hydrochloride (LY3298176 hydrochloride) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is develope for the treatment of type 2 diabetes [1] . However, Buy Tirzepatide Online 99% powder

What is the mechanism of action of tirzepatide on HEK293 cells?

Also, In HEK293 cells, Tirzepatide induces internalization of the GIPR and have a propensity toward partial agonism, and this ultimately reflects in signaling bias toward the cAMP pathway versus β-arrestin recruitment. [1] LY3298176 shows glucose-dependent insulin secretion and improves glucose tolerance by acting on both GIP and GLP-1 receptors in mice.

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