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3-MeO-PCP (also known as 3-Methoxyphencyclidine) is a lnovel dissociative substance of the arylcyclohexylamine class. 3-Methoxyphencyclidine is a derivative of phencyclidine (PCP) and is chemically related to substances like methoxetamine and 3-MeO-PCE. It produces its effects by blocking NMDA receptors in the brain.

Cas No: 91164-58-8
Formula: C18H27NO • HC1
IUPAC: 1-[1-(3-Methoxyphenyl)cyclohexyl]-piperidine
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Buy 3-MeO-PCP Online

Buy 3-MEO-PCP POWDER Online. 3-Methoxyphencyclidine (also known as 3-MeO-PCP) is a lesser-known novel dissociative substance of the arylcyclohexylamine class. 3-MeO-PCP is a derivative of phencyclidine (PCP) and is chemically related to substances like methoxetamine and 3-MeO-PCE. It produces its effects by blocking NMDA receptors in the brain.

3-MeO-PCP was first synthesize in 1979 in an investigation of phencyclidine (PCP) derivatives. However, its activity in humans is not describe until 1999 when a chemist using the pseudonym John Q. Beagle reports qualitative similarities to PCP along with comparable potency.

Like other arylcyclohexylamines, 3-MeO-PCP induces a state refer to as “dissociative anesthesia”, although the extent to which this occurs is  to be highly dose-dependent and variable in its effects. It is commonly taken orally and nasally, although it may also be smoke.

 

Chemistry

3-Methoxyphencyclidine, or 3-MeO-PCP, is a synthetic dissociative of the arylcyclohexylamine class. 3-MeO-PCP contains cyclohexane, a six-member saturate ring, bonds to two additional rings at R1. One of these rings is a piperidine ring, a nitrogenous six member ring, bonds at its nitrogen group. The other ring is an aromatic phenyl ring, substitute at R3 with a methoxy group.

3-MeO-PCP is a PCP derivative and structurally analogous to 4-MeO-PCP.

 

Pharmacology

Further information: NMDA receptor antagonist
3-MeO-PCP acts as an NMDA receptor antagonist. A specific subtype of glutamate receptor. NMDA (N-Methyl-D-Aspartate), modulates the transmission of electrical signals between neurons in the brain and spinal cord. For the signals to pass, the receptor must be open.

Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity leads to loss of normal cognitive and affective processing, psychomotor functioning, anesthesia and eventually the equivalent of a “k-hole”.

3-MeO-PCP has a Ki of 20 nM for the NMDA receptor, 216 nM for the serotonin transporter (SERT), 42 nM for the sigma-1 receptor and 2960 nM with H1 receptor. It binds to the NMDA receptor with higher affinity than PCP and has the highest affinity of the three isomeric anisyl-substitutions, followed by 2-MeO-PCP and 4-MeO-PCP.

Subjective Effects

3-MeO-PCP is commonly describe as being more stimulating and less immobilizing than other dissociatives such as ketamine or MXE. At lower doses, it can induce sensory enhancements such as color enhancement, acuity enhancement, tactile enhancement. Auditory enhancement and bodily control enhancement. However, at medium to high doses, it presents sensory suppressions such as tactile suppression, motor control loss.  Auditory suppression and acuity suppression. Base on a large amount of experience reports, it appears to be considerably more likely to induce mania, delusions, and psychosis. Than other dissociatives (possibly due to its unusually high potency, compulsivity and erratic dose response).

 

Physical Effects

Stimulation – 3-MeO-PCP is regarded to be noticeably stimulating in comparison to other dissociatives such as ketamine, MXE, or DCK. The stimulation it presents describes as clear and subtle.

Spontaneous bodily sensations – The body high of 3-MeO-PCP can be describe in terms of its style variations as a motionless, constant, sharp, all-encompassing nerve endings across the body.
Tactile enhancement or Tactile suppression – At lower dosages, this compound tends to induce tactile enhancements. At higher dosages, this enhancement shifts towards tactile suppressions and anesthesia.
Pain relief – This substance produces distinct nerve-signal blocking anesthetic effects typically require in surgical settings, but only in the stronger to heavier dose ranges.

Tolerance to many of the effects of 3-MeO-PCP develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 – 7 days for the tolerance to be reduced to half and 1 – 2 weeks to be back at baseline (in the absence of further consumption). 3-MeO-PCP presents cross-tolerance with all dissociatives, meaning that after the consumption of 3-MeO-PCP, all dissociatives will have a reduced effect.

 

Urinary frequency – Urinary frequency is the need to empty the bladder every few minutes.
Also, Urinary urgency – This can be described as a sudden, compelling need to urinate.
Urinary pressure – This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
Pelvic and bladder pain – Pain can develop suddenly and severely, particularly as the bladder fills with urine.
Hematuria – Hematuria is visible blood in the urine.
Incontinence – This is the leakage of urine.
These effects can be mitigated by refraining from using 3-MeO-PCP regularly (on a daily or weekly basis) and manually limiting one’s usage of the substance. Buy 3-MEO-PCP POWDER Online

Depressants

– Because both depress the respiratory system, this combination can result in an increased risk of suddenly falling unconscious, vomiting and choking to death from the resulting suffocation. If nausea or vomiting occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.

 

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