Cannabinoid News and Updates. When it comes to the medicinal and therapeutic properties of Cannabis sativa, an unsolved mystery is whether there exists an “entourage effect,” whereby the pain-relieving effects of the plant as a whole are greater than any of its individual parts. New research from the University of Arizona Health Sciences has found evidence that favors the entourage effect theory and positions Cannabis terpenes, the part of the plant that provides flavor and aroma, as a promising new target for pain therapies that would require lower doses and produce fewer side effects.

Terpenes are aromatic compounds found in many plants and are the basic component in essential oils. The terpene linalool, for example, gives lavender its distinctive floral scent. In addition to terpenes, Cannabis sativa contains naturally occurring compounds known as cannabinoids, the most well-known of which are cannabidiol, or CBD, and tetrahydrocannabinol, or THC, the psychoactive component of cannabis.

Researchers found that Cannabis terpenes, when used by themselves, mimic the effects of cannabinoids, including a reduction in pain sensation. When combined with cannabinoids, the pain-relieving effects were amplified without an increase in negative side effects. The paper, “Cannabis sativa terpenes are cannabimimetic and selectively enhance cannabinoid activity,” was published in Scientific Reports.

Dr. Streicher and the research team, including former graduate student and first author Justin LaVigne, PhD, former undergraduate researcher Ryan Hecksel and former postdoctoral fellow Attila Kerestztes, PhD, focused on four Cannabis terpenes: alpha-humulene, geraniol, linalool and beta-pinene. They evaluated each terpene alone and in combination with WIN55,212-2, a synthetic cannabinoid agonist that stimulates the body’s natural cannabinoid receptors.

When a cannabinoid such as THC enters the body, it binds to one of two cannabinoid receptors – CB1R, which is the most abundant, or CB2R. The receptor then activates neurons that affect physiological processes and behavior. In laboratory experiments, researchers found that all four terpenes activated the CB1R, just like THC. Cannabinoid News and Updates

Behavioral studies in mouse models revealed that when administered individually, all four terpenes lowered pain sensitivity, and at least three of the four classic cannabinoid side effects: reduced pain sensation, lowered body temperature, reduced movement and catalepsy, a freezing behavior related to the psychoactive effects of cannabinoids. When terpenes were combined with WIN55,212-2, researchers saw a greater reduction in pain sensation compared with either the terpene or WIN55,212-2 alone, demonstrating a terpene/cannabinoid interaction in controlling pain.

Dr. Streicher’s ongoing research is focusing on the use of terpenes in combination with opioids and for specific types of cancer-related pain. His long-term goal is to develop a dose-reduction strategy that uses terpenes – generally recognized as safe by the U.S. Food and Drug Administration – in combination with cannabinoids or opioids to achieve the same levels of pain relief with lower doses of drugs and fewer side effects.http://Buy Benzodiazepine online,Online sales Cannabinoid ,Cathinones online shop worldwide,Best onle sales Empathogens,Online sales of Opioids,Buy Psychedelics Online,Research Chemicals online shop, Buy Benzodiazepine online,Online sales Cannabinoid ,Cathinones online shop worldwide,Best onle sales Empathogens,Online sales of Opioids,Buy Psychedelics Online,Research Chemicals online shop,Buy Stimulants online,Shop online Buprenorphine Powder,Buy 1p-LSD online,Buy Etizolam Powder Online,Buy Bromadol Hcl Powder,Buy U-47700 powder,Buy Fentanyl powder,Buy 4-CL-PVP Crystal online,Buy DOC Powder,Buy clonazolam powder,Buy a-PVP Online,Buy Ephedrine powder,Buy U-48800 powder,Buy Furanyl fentanyl powder,online Tramadol Powder sales, Buy Bromadol Hcl Powder online,Buy 2C-C Powder,Buy 4F-PHP Crystal online,Buy Isopropylphenidate Powder,Buy 3-MMC Crystal,Buy 3-FEA Powder,Buy Synthacaine Powder,Buy 6-APB Powder,Buy Ephenidine Powder,Buy Dimethocaine Powder,Buy amb-fubinaca Powder,Buy MAB-CHMINACA Powder,Buy Methoxphenidine Powder,Buy Methoxphenidine Crystal,Buy MMB-CHMINACA Powder,Buy SGT-151 Powder,Buy NM-2201 Powder,Buy Phenzacaine Powder,Buy SDB-005 Powder,Buy TH-PVP Crystal,5F-AKB57 Powder,Buy 5-APB Powder,Buy 4-CEC Crystal,Buy 3-MEC Crystal,Buy 2-NMC Crystal,Buy 2-FDCK Crystal,Buy N-Ethylhexedrone Crystal,Buy N-Ethylhexedrone Crystal,Buy N-Ethylhexedrone Powder,Buy 3-FPM Crystal,Buy Diphenidine Powder,Buy 5F-ADB Powder,Buy 5F-ADB Powder,Buy 3-MeO-PCE Powder,Buy 3-MeO-PCP Powder,Buy 3,4-CTMP Powder,Buy 3-4-MD-a-PBP Powder,Buy 4-Fluoro-MPH Powder,Buy BK-2C-B Powder,Buy EG-018 Powder,Buy MDAI Powder,Buy MDMB-CHMCZCA Powder,Buy MDMB-CHMINACA Powder,Buy MDPHP Powder.