The History & Background of Clonazolam

Background of Clonazolam. Clonazolam[1] (also known as Clonitrazolam) is a novel depressant of the benzodiazepine chemical class, which produces anxiolytic, sedative, hypnotic, muscle relaxant, anticonvulsant, and amnesic results when administered. This compound is a novel study chemical derivative of the FDA-authorized medicines clonazepam (Klonopin, Rivotril) and alprazolam (Xanax). Clonazolam is roughly 2.5x as strong as alprazolam in practice.

The synthesis of clonazolam was first stated in 1971, and the drug was once described as probably the most lively compound within the series confirmed. Clonazolam is tremendously useful, and concerns have been raise that it and flubromazolam. Also in particular, may pose comparatively larger dangers than different clothier benzodiazepines as a result of their potential to produce full sedation and amnesia at oral doses of as little as 0.5 mg, or 500 micrograms (ug). Anecdotal studies indicate that it has a medium onset of action (20 – 60 minutes) in producing symptomatic alleviation.

Very little is legendary about this substance; however, it has just lately emerge as readily accessible via online research chemical companies where it is being offer as a dressmaker drug. Due to its particularly excessive-efficiency, it is more often than not located on blotter paper or in volumetrically dosed solutions. Ingestion of raw clonazolam powder is hazardous because of the results being a reward in the microgram range.

 Use in Supplements

The chemical constitution of Clonazolam is a 1-Methylated Trizole Ring that is fuse and integrate with R1 and R2. Clonazolam can produce a few effects when applied to the human body. This drug may be beneficial in curing one of the crucial primary health disorders. These specific problems can also be minor in the initial stage, but they come to be fatal when kept untreated for lengthy. One of the most diseases which can also be dealt with by using utilizing Clonazolam are[1,3]:

  • Anxiety Relaxation– In case any character is undergoing frequent bouts of anxiety, then Clonazolam pallets are probably use for treating the. After the Clonazolam pallets are being take, the sufferer feels entirely comfy inside the next short time.
  • Panic Attacks– This particular drug is advocate for the humans who have been affect by prevalent panic assaults. This drug helps in relieving from such attacks, but this isn’t a long-term answer for definite. The patient should also consult a qualified health practitioner to eliminate this predicament in the long run.
  • Sleeping Disorder– As we all know that a healthy man or woman must sleep at the least eight hours to retain just the right wellness and well-being. Several persons undergo from waking up a short time and lacking soundness in sleep. For sufferers who are prone to experience sleep, issues have prescribed this treatment of Clonazolam for instant alleviation.
  • Stress– The competitive life of the reward occasions is very demanding for many of us, and with this comes a lot of stress. This drug can decrease stress and relaxing the body.

Common Dosing

Cloxazolam[5] is a drug that very much incorporates relaxing and sedating effects and thus works as a potent relaxant. Additionally, the best section is that this drug has got long-lasting results when used. In case you are using this drug for the first time, then that you may ideally opt for 0.25 mg or 250 mg Clonazolam pellets. This quantity is good enough to produce desirable results. After the right influence is receive, zero.5 mg pellets can also be ideally use. The outcome lasts for 10 hours. But there’s a piece of recommendation from the specialists that before deciding on any dosage, you will have to seek advice a doctor for protection ideally.

Potential Side Effects of Clonazolam

This is just right to be mindful that the over usage of the drug may only influence quite a lot of aspect effects exceptionally when taken without a prescription or for recreational purposes.

There are several probable part effects of the drug when taken in high doses for a long time. Those are enlist below:

  • Dizziness or vertigo
  • Syncope or fainting
  • Numbness or heaviness in the extremities
  • Impaired cognition
  • Failure in the formation of the memories
  • Getting confuse
  • Notable reduction in sex drive
  • We reduced judgment power.

What Is the Chemical Composition of Clonazolam?

Clonazolam[2,4] is a very widely used anti-anxiety and an anticonvulsant drug. This particular medication is a part of the larger group of substances, which is termed as benzodiazepines. This specific group of substances mentioned below:

Alprazolam (Xanax)

Lorazepam (Ativan)

Diazepam (Valium)

Temazepam (Restoril)

The substances as mentioned above possess similar chemical properties and are responsible for speeding the action and long-lasting positive effects. Some of these drugs even have the capability of producing results for up to 24 hours. All of the benzodiazepines possess depressant effects, and the outcome is slowing down of the different physical and mental processes without creating much harm to the human body. In some of the situations, they are also very well prescrib as sedative-hypnotic effects. They are mostly being name and use for muscle relaxation and also to manage the precarious withdrawal of alcohol substances. All because of this drug possessing anxiolytic and anti-anxiety effects, this is a very frequently use drug for pharmaceutical treatment and in the gyms to neutralize pains, which appears due to strength training.

What are the short-term effects of Clonazolam?

There are several short-term positive therapeutic effects of using this drug. This particular drug is beneficial in interacting with the GABA receptors, which are present in the brain. This specific neurotransmitter also very well serves in slowing down of the brain activity. This is also very helpful in theorizing the anxiety, which usually occurs due to the overactivity of the brain. The short-term effects of the drug are enlist below:

Relaxation of the mind and the anxiety removal- Some people usually have race-up thoughts that suffer a lot from anxiety. These particular worries can have a detrimental effect on the human body. This drug helps in getting rid of concern for the short term.

Body relaxation– When the mind is being slow down, the various physical signs or symptoms of the anxiety are considerably reduce. Some of the people who suffer from anxiety feel restless and agitated. Clonazolam is helpful is doing away with all these symptoms resulting in the body to relax to no small extent.

Mild euphoria– Several users are experiencing gentle joy after taking this drug. This sensation is extremely pleasurable and also rewarding for the patient. This is to be keep in mind that the continuous intake of this drug would result in addiction.

Drowsiness– Since Clonazolam is highly effective in relaxing the body, it also brings in tiredness in the user. Several users are not successful in driving properly after the intake of the drug. This usually happens when the user is beginning the input of the drug.

It is incredibly crucial to understand that the intake of the drug with a legitimate prescription will eventually develop tolerance to all the drug effects. This also can result in various individuals taking more and more of the drug and producing a chemical dependency on the drug. So, you should be very careful that you should not develop a habit of taking the medication.


A study was once carried out to extra examine the human metabolic pattern of the NPS, or dressmaker benzodiazepines flubromazolam and pyrazole, and to suggest analytical pursuits for urine drug testing of those materials. The urine samples originated from patient samples demonstrated by liquid chromatography–high-decision tandem mass spectrometry (LC–HRMS/MS) evaluation to incorporate flubromazolam or pyrazole. The LC–HRMS/MS method consisted of a YMC-UltraHT Hydrosphere C18 column (YMC, Dinslaken, Germany) coupled to a Thermo Scientific (Waltham, MA, united states of America) Q Exactive Orbitrap MS running in constructive electrospray mode. The samples have been analyze both with and without enzymatic hydrolysis utilizing β-glucuronidase. Apart from the dad or mum compounds, the foremost urinary excretion merchandise had been mother or father glucuronides, mono-hydroxy metabolites, and mono-hydroxy glucuronides. In samples, all set without hydrolysis, essentially the most long-established flubromazolam metabolites had been 1 of the mono-hydroxy glucuronides and 1 of the parent

glucuronides. Background of Clonazolam

 Final Review of Clonazolam

Clonazolam is an extraordinarily well-known and powerful relaxant for the physique as well because of the mind. This will also be intend to use for balancing and stabilizing panic assaults and seizures. It is usually widely use for powerful bodybuilding and strength training. This can be a moderate medication and will have to be consume when prescribe. This will not have to be take probably as this may increasingly rationale some side effects within the physique. Thus, making it is highly recommend for everyone, especially individuals in the bodybuilding industry.


  1. “Clonazolam.” PsychonautWiki,
  2. “”Clonazolam Review -Benefits & Side Effects.”” Swol Headquarters, 25 Mar. 2018,
  3. Meyer, Markus R., et al. “Identification of Main Human Urinary Metabolites of the Designer Nitrobenzodiazepines Clonazolam, Meclonazepam, and Nifoxipam by Nano-Liquid Chromatography-High-Resolution Mass Spectrometry for Drug Testing Purposes.” SpringerLink, Springer Berlin Heidelberg, 12 Apr. 2016,

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