4-FLUOROMETHYLPHENIDATE. COLORADO SPRINGS — The Colorado Springs Fire Department has identified the white substance that was spilled down a street in Colorado Springs that caused closures as Lye.
Lye is a mineral used for washing or cleansing. It was found just north of the intersection of East Las Vegas Street and South Circle Drive.
Crews say a shipping company will be cleaning up the Lye. In the meantime, East Las Vegas Street will be closed in both directions until the road is cleared
Higher Binding Potency
A study has found that the meta- and para-substituted compounds with electron-withdrawing substituents in the threo-isomers of methylphenidate have increased binding potency. Compounds containing fluorine, chlorine, bromine and methyl groups were reported to be more potent than methylphenidate. Since 4F-MPH has fluorine, it has higher binding potency as dopamine reuptake inhibitor. It was reported as having ED50 mg/kg of 0.26 and a relative potency of 3.33 to Methylphenidate. 4-FLUOROMETHYLPHENIDATE
4F-MPH can boost neurotransmitters
4F-MPH acts as a dopamine reuptake inhibitor (DRI), which means it effectively boosts the levels of dopamine neurotransmitters in the brain. It binds or blocks the transporter proteins that remove monoamines from the synaptic cleft, resulting in the accumulation of dopamine within the brain. This causes stimulating and euphoric effects
Chemicals that act as DRIs are used in the treatment of attention-deficit hyperactivity disorder (ADHD) and narcolepsy for their psychostimulant effects. They are also sometimes used in the treatment of obesity and binge eating disorder for their appetite suppressant effects. They can be used as antidepressants in the treatment of mood disorders. However, due to their higher potency their usage as antidepressants is limited. Lack of dopamine reuptake due to continuous usage of 4F-MPH has been linked to increased susceptibility to addictive behavior.
Previously stimulant drugs with DRI action have been used clinically include: amineptine, dexmethylphenidate, difemetorex,fencamfamine, medifoxamine, nomifensine, prolintane, and pyrovalerone. Though all these drugs have different modes of action, so the pharmacotherapeutic use of 4F-MPH and its mode of action is yet to be discovered by the scientific community. Since this stimulant drug acts as DRI it can serve as nicotine replacement in cases of smoking addiction and methadone replacement in the case of heroin addiction. 4-FLUOROMETHYLPHENIDATE
Where to buy 4F-MPH for research purpose?
Researchers and scientists can buy 4F-MPH pellets from trusted online vendor for research chemicals in the EU or their local area. Remember to buy only high quality research chemicals with 99.9% purity in order to obtain good research results.
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